منابع مشابه
Predicting Alloreactivity in Transplantation
Human leukocyte Antigen (HLA) mismatching leads to severe complications after solid-organ transplantation and hematopoietic stem-cell transplantation. The alloreactive responses underlying the posttransplantation complications include both direct recognition of allogeneic HLA by HLA-specific alloantibodies and T cells and indirect T-cell recognition. However, the immunogenicity of HLA mismatche...
متن کاملAlloreactivity-Based Medical Conditions
1 Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Medical Center, Washington, DC 20010, USA 2Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, MO 66160, USA 3Department of Pediatrics, University of Washington, Seattle Children’s Hospital, Seattle, WA 98109, USA 4Department of Physiology and Immunology, University of Rijeka, 5...
متن کاملDirect alloreactivity is more susceptible to regulation by natural regulatory T cells than indirect alloreactivity.
The contribution of natural CD4(+)CD25(+) regulatory T cells (nTregs) in controlling graft rejection and the mechanism used remain controversial. Using the duality of the 2.102 TCR Ag recognition, we were able to study, for the first time to our knowledge, the involvement of nTregs in the two pathways of allorecognition in a murine adoptive transfer model in which TCR-transgenic nTregs were or ...
متن کامل62 Analysis of T Cell Alloreactivity
The genetic and biochemical basis for the inclusion of T cell alloreactivity within the immunological repertoire of T helper (Tn) 1 lymphocytes remains a perplexing problem (1, 2). Recent evidence (3-9) suggests that the ability of Tn cells to bind to molecular complexes formed on antigen-presenting ceils between a nominal antigen and either self or nonself (allo) Ia molecules regulates their d...
متن کاملBidirectional Grammar and Bidirectional Optimization
The human language faculty is a bidirectional system, i.e. it can be used by processes of approximately equal computational complexity to understand and to generate utterances of a language. We assume the general framework of optimality theory and treat the language faculty as a constraint-based system where the very same constraints are uses both in comprehension and in generation. In the simp...
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ژورنال
عنوان ژورنال: Chimerism
سال: 2012
ISSN: 1938-1956,1938-1964
DOI: 10.4161/chim.21668